Life Course Immunisation (LCI) presents an advocacy framework for protection against vaccine-preventable diseases throughout the course of our lives. Investing in a life-course approach in national immunisation programmes brings wide health and economic benefits, protects all ages from vaccine-preventable infectious diseases, and reduces disease burden, better preparing us all to live longer and more productive lives. In a context where older persons comprise the world’s fastest-growing age group, maintaining a healthy, fit older population will become very important for individuals. LCI strategies are a cost-effective means of improving health throughout the duration of adult life. Adult vaccination not only reduces the incidence and severity of infectious diseases but also reduces the incidence and severity of comorbidities with noncommunicable conditions.