Vaccination serves as the most effective and foundational pillar of infection prevention at all life stages. A comprehensive lifecourse immunisation strategy which includes concrete targets for maternal immunisation, and their infant protection, adolescents, all individuals in clinical groups at risk, and older adults’ vaccination coverage against respiratory infections is of significant importance. This Call for Action articulates a shared vision of a Europe where every person is protected from vaccine-preventable diseases at every stage of life. It aims to strengthen population resilience across the life course by reducing avoidable reliance on reactive healthcare and advancing preventive, value-based approaches that enable individuals to sustain health, autonomy, and self-direction.